In this thesis we investigate the topological nature of the Collet-Eckmann condition for S-unimodal maps of the interval. The Collet-Eckmann condition holds, by definition, if the Lyapunov exponent is positive along the orbit of the critical point; this is a metric condition. It implies that the Lyapunov exponent is positive Lebesgue almost everywhere and that the map is chaotic. We relate topological and metric properties using an extended form of Hofbauer's tower construction. The main results are as follows: We prove that the Collet-Eckmann condition is invariant under quasi-symmetric conjugacy between S-unimodal maps. We show that any S-unimodal map whose kneading invariant satisfies certain simple conditions satisfies the Collet-Eckmann condition. The conditions are topological analogues of those used by Benedicks and Carleson in their proof of Jakobson's theorem. We also give examples of kneading invariants corresponding to failure of the Collet-Eckmann condition. This falls short of a complete classification of kneading invariants into Collet-Eckmann or non-Collet-Eckmann. We prove that Lebesgue almost every value of the topological entropy has the property that any S-unimodal map with that topological entropy must satisfy the Collet-Eckmann condition. This is analogous to Lebesgue almost every rotation number having the property that any smooth circle map with that rotation number must possess an absolutely continuous invariant measure. These results form part of a topological proof of Jakobson's theorem; it remains only to show that Collet-Eckmann kneading invariants are taken on for a positive measure set of parameter values in the quadratic family.